The Use of Multifactor Dimensionality Reduction to Detect Epistasis Among Potential Causal Genes of Alcoholism
نویسنده
چکیده
Epistasis, the interaction among genes, is ubiquitous among common, complex, and multifactorial diseases. Therefore it has become necessary to develop methods to detect epistasis, the motivation for one such method, multifactor dimensionality reduction (MDR). We introduce the algorithm of MDR, its strengths and weaknesses, and finally illustrate the results of applying MDR to alcoholism. We compare these results to those from logistic regression, a commonly used alternative to MDR, and discuss methodological issues of MDR, and future work centered around these issues.
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